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05/26/2022

Detailed explanation of HRIPT/RIPT Human Repetitive Injury Patch Test Required for Amazon Cosmetics Review

05/26/2022
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Detailed explanation of HRIPT/RIPT Human Repetitive Injury Patch Test Required for Amazon Cosmetics Review

What is a cosmetic HRIPT/RIPT?

HRIPT: Human Repeated Insult Patch Test (HRIPT)

RIPT: Chinese is a repeated fully enclosed skin patch test. It is currently the most rigorous research that does not cause potential irritation or allergy after using products or raw materials. Nine groups of induced patches are used, followed by one group after a period of rest. Trigger test.

Amazon requires makeup and beauty products to do this test

To ensure that no potential irritation or allergy develops after using the product or ingredients. Amazon requires cosmetics, beauty products, nail glue, etc. to do HRIPT/RIPT multiple repeated closed skin patch test reports. After the sample arrives at the laboratory, the test substance will be assigned an independent laboratory test number and will be recorded in the laboratory log to verify the batch number, sample specification, sponsor, date of receipt and test request.

Volunteer screening: According to the opinion of the research and development staff, the tester must not have any systemic disease or skin disease history, otherwise it will hinder the test results or increase the risk of adverse reactions in the body. If the skin color is suitable for erythema test observation, any skin nature Anyone of any race can participate, and a research sample of 53 people was finally screened. The test is divided into an induction period and a challenge period. Through repeated tests, it is finally determined whether the subjects have erythema or other adverse stimulation reactions.

Approved by Amazon.

Review emails required by Amazon

Product Safety requires you to take the following steps in response to the above questions:

1. The most important inquiry: Submit all relevant safety test data and certificates of the item. We ask that you include a test specific to the event in question. If in doubt, please refer to the text document accompanying the Product Compliance Guide. Please note: MSDS is not sufficient for security testing.

2. Please provide evidence that the product has been HRIPT/RIPT tested or other skin irritation tests and COA. If in doubt about the appropriate standard for a product, please contact the laboratory directly for advice.

3. Complete the enclosed Product Safety Questionnaire. This questionnaire is designed to address security concerns raised by customers. Contact the product manufacturer for details you may not have.

4. Provide product images (front, back, accessories and packaging). Images should include: model/serial number on the product or packaging, safety/compliance markings and logos, and safety labels and warnings. Please also attach a copy of the instruction manual.

Purpose:

This paper introduces the role of Human Repeated Insult Patch Test (HRIPT) in the safety evaluation of cosmetics, and uses this method to evaluate the safety of 11 kinds of cosmetics. Methods: Human repetitive injury patch test was performed on 11 kinds of cosmetics among 53 volunteers. During the induction period, the patch test was repeated 9 times on the same part of the back. After 2 weeks of rest, the challenge test was performed on the skin of the non-patch site. , the patch was scored after 24h, 48h and 72h.The test results were interpreted with reference to the ICDRG scoring standard of the International Contact Dermatitis Research Group. According to the nature of the cosmetic, closed or semi-closed plaque testers were selected, 0.3%-0.5% SLS was used as a positive control, and Vaseline and blank plaque testers were used as negative. Control, results: 7 of the 11 tested cosmetics showed mild irritation, 1 subject had been allergic to one of the cosmetics before the test, and none of the 11 tested products had induced allergic reactions , Conclusion: Human repetitive injury patch test has high sensitivity, can clearly distinguish irritation, sensitization and potential sensitization, and can be used as a confirmatory test for the safety of cosmetics

In summary:

HRIPT achieves a magnification effect compared with the actual use by adopting the method of prolonging the exposure time, using a higher concentration and closing the patch, and can detect extremely weak stimulus responses, indicating the possible risks in actual use. A negative HRIPT result can prove that the body does not have an adverse reaction to a particular product or formulation.However, it should be noted that: for ethical reasons, the HRIPT test is not used to predict or screen and identify potential allergens, but is mainly used as a confirmatory test to detect allergens in formulations under the conditions of scaled-up applications to ensure that Product safety for consumer applications

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